Dose painting en planificación de RT en pacientes con cáncer de cuello uterino a través de imágenes PET/MR. / Dose painting in RT planning patients with cervical cancer trough.

Velásquez Silva, Ángel T. (2018) Dose painting en planificación de RT en pacientes con cáncer de cuello uterino a través de imágenes PET/MR. / Dose painting in RT planning patients with cervical cancer trough. Master in Medical Physics, Universidad Nacional de Cuyo, Instituto Balseiro.

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Abstract in Spanish

Las imágenes PET/MR con FDG utilizadas actualmente para diagnóstico de cáncer de cuello uterino en el servicio de Medicina Nuclear de la Fundación Escuela de Medicina Nuclear (FUESMEN) son útiles para la confirmación de la enfermedad y su completa estadificación. Además de que brindan información relevante para la planificación de tratamiento de radioterapia (RT) al permitir diferenciar tejidos blandos en pelvis así como también la anatomía y metabolismo ganglionar. El presente trabajo se centró en la utilización de un protocolo de adquisición de imágenes multiparamétricas PET/MR para la panificación de tratamientos en cáncer de cuello uterino, a partir del comportamiento metabólico tumoral y su correlación con imágenes anatómicas y funcionales lo que permitió definir un nuevo volumen blanco en la planificación del tratamiento de RT, denominado BTV (Biological Target Volume). Con la definición de este nuevo volumen se realizó una planificación basada en dose painting aplicando un refuerzo de dosis integrado simultáneo (SIB: Simultaneous Integrated Boost). Para esta planificación se utilizaron las imágenes PET/MR fusionadas con la tomografía computarizada (CT) de planificación para una mejor caracterización de la lesión tumoral permitiendo alcanzar un escalamiento de dosis utilizando las técnicas de IMRT.

Abstract in English

PET / MR images with FDG are used for the diagnostic of cervical cancer of the Nuclear Medicine service of FUESMEN are useful for the confirmation of the disease and its complete staging. In addition to providing relevant information for the treatment planning by allowing differentiate soft tissues in the pelvis, as well as the anatomy and the lymph node metabolism. The present work focused on the use of a multiparametric PET/MR image acquisition protocol for the making of treatments in cervical cancer, based on the tumor metabolic behavior and its correlation with anatomical and functional images so that they can define a new target volume in the treatment planning of RT, designate BTV (Biological Target Volume). With the definition of this new volume, a planning based in dose painting was carried out applying a simultaneous integrated boost (SIB). For this planning was used the PET/MR images fused with the planning’s CT for a better characterization of the tumor lesion allowing reach a dose escalation using the IMRT techniques.

Item Type:Thesis (Master in Medical Physics)
Keywords:Uterine cervix carcinoma; Cáncer de cuello de útero; Dose painting
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Subjects:Medicine > Medicina nuclear
Medicine > Radiotherapy
Divisions:Fundación Centro de Medicina Nuclear y Molecular de Entre Ríos
ID Code:771
Deposited By:Tamara Cárcamo
Deposited On:24 Feb 2021 10:17
Last Modified:24 Feb 2021 10:17

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