Soriano Ruiz, Luis E. (2023) Caracterización de rendimiento de blanco de 68Ga a partir de 68Zn mediante irradiación con protones en ciclotrón de 11 Mev / 68Zn/68Ga Cyclotron target yield characterization using 11 Mev proton beam irradiation. Maestría en Física Médica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
Debido a múltiples ventajas, actualmente la producción en ciclotrón de 68"Ga, para la marcación de radiofármacos PET, se está convirtiendo en una alternativa cada vez más viable frente a los tradicionales generadores 68"Ge/68"Ga. Al presente, los ciclotrones más vendidos poseen haces de protones con energías de 16.5 a 18 MeV. A partir de simulación Monte Carlo, este trabajo evalúa la potencialidad de producción de 68"Ga en blancos sólidos y líquidos utilizando ciclotrón con energía nominal de haz de protones significativamente menor, de 11 MeV. Las simulaciones en FLUKA se realizaron en base a las composiciones isotópicas y contaminantes reportados por los fabricantes de los sustratos para blancos sólidos y líquidos del 68"Zn enriquecido, un modelado geométrico simplificado, modelado del haz ajustado sobre parámetros físicos reales del ciclotrón, el transporte y la detección de distintas magnitudes relevantes. Se determinaron los rendimientos de saturación para la producción de 68"Ga de blancos con y sin refrigeración anterior mediante He. Los blancos sólidos presentan valores de GBq/μA, mientras que para los blancos líquidos el orden de magnitud es de MBq/μA, concordantes con los valores experimentales reportados en la literatura. Simultáneamente, fue posible determinar la producción de radioisótopos contaminantes debido a las reacciones nucleares colaterales, coincidiendo varios de ellos con radioisótopos encontrados experimentalmente por otros autores.
Resumen en inglés
Nowadays the 68"Ga production for PET radiopharmaceuticals is moving from the already established technique based on 68"Ge/68"Ga generators to a cyclotron target irradiation alternative since it offer numerous advantages. At present the greatest commercial demand is focused on proton energy cyclotron ranging from 16.5 to 18 MeV.This work relies on Monte Carlo simulation techniques to study the potential of 68"Ga production with solid and liquid targets by using the locally available 11 MeV proton beam cyclotron. The FLUKA simulations were performed considering the isotopic compositions and contaminants reported by the manufacturers of the enriched 68"Zn substrates for solid and liquid targets, a simplified geometric modeling, beam modeling tailored to the actual physical parameters, transport and detection of a number of relevant quantities. 68"Ga saturation yields were determined for targets with and without front He gas cooling. Solid targets show magnitudes of GBq/μA while liquid targets are MBq/μA order. Those results are consistent with experimental values reported on the literature. It was also possible to determine contaminating radioisotopes production due to collateral nuclear reactions, many of them match with radioisotopes experimentally found by other authors.
| Tipo de objeto: | Tesis (Maestría en Física Médica) |
|---|---|
| Palabras Clave: | Proton beams; Haces de protones; [FLUKA; Liquid target; Blanco líquido; Solid target; Blanco sólido; Monte Carlo simulation; Simulación Monte Carlo; Cyclotron; Ciclotrón] |
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| Materias: | Física > Física médica |
| Divisiones: | FUESMEN |
| Código ID: | 1232 |
| Depositado Por: | Marisa G. Velazco Aldao |
| Depositado En: | 11 Abr 2024 12:27 |
| Última Modificación: | 11 Abr 2024 14:56 |
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