Soriano Ruiz, Luis E. (2023) Caracterizacin de rendimiento de blanco de 68Ga a partir de 68Zn mediante irradiacin con protones en ciclotrn de 11 Mev / 68Zn/68Ga Cyclotron target yield characterization using 11 Mev proton beam irradiation. Maestra en Fsica Mdica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en espaol
Debido a mltiples ventajas, actualmente la produccin en ciclotrn de 68"Ga, para la marcacin de radiofrmacos PET, se est convirtiendo en una alternativa cada vez ms viable frente a los tradicionales generadores 68"Ge/68"Ga. Al presente, los ciclotrones ms vendidos poseen haces de protones con energas de 16.5 a 18 MeV. A partir de simulacin Monte Carlo, este trabajo evala la potencialidad de produccin de 68"Ga en blancos slidos y lquidos utilizando ciclotrn con energa nominal de haz de protones significativamente menor, de 11 MeV. Las simulaciones en FLUKA se realizaron en base a las composiciones isotpicas y contaminantes reportados por los fabricantes de los sustratos para blancos slidos y lquidos del 68"Zn enriquecido, un modelado geomtrico simplificado, modelado del haz ajustado sobre parmetros fsicos reales del ciclotrn, el transporte y la deteccin de distintas magnitudes relevantes. Se determinaron los rendimientos de saturacin para la produccin de 68"Ga de blancos con y sin refrigeracin anterior mediante He. Los blancos slidos presentan valores de GBq/μA, mientras que para los blancos lquidos el orden de magnitud es de MBq/μA, concordantes con los valores experimentales reportados en la literatura. Simultneamente, fue posible determinar la produccin de radioistopos contaminantes debido a las reacciones nucleares colaterales, coincidiendo varios de ellos con radioistopos encontrados experimentalmente por otros autores.
Resumen en ingls
Nowadays the 68"Ga production for PET radiopharmaceuticals is moving from the already established technique based on 68"Ge/68"Ga generators to a cyclotron target irradiation alternative since it offer numerous advantages. At present the greatest commercial demand is focused on proton energy cyclotron ranging from 16.5 to 18 MeV.This work relies on Monte Carlo simulation techniques to study the potential of 68"Ga production with solid and liquid targets by using the locally available 11 MeV proton beam cyclotron. The FLUKA simulations were performed considering the isotopic compositions and contaminants reported by the manufacturers of the enriched 68"Zn substrates for solid and liquid targets, a simplified geometric modeling, beam modeling tailored to the actual physical parameters, transport and detection of a number of relevant quantities. 68"Ga saturation yields were determined for targets with and without front He gas cooling. Solid targets show magnitudes of GBq/μA while liquid targets are MBq/μA order. Those results are consistent with experimental values reported on the literature. It was also possible to determine contaminating radioisotopes production due to collateral nuclear reactions, many of them match with radioisotopes experimentally found by other authors.
| Tipo de objeto: | Tesis (Maestra en Fsica Mdica) |
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| Palabras Clave: | Proton beams; Haces de protones; [FLUKA; Liquid target; Blanco lquido; Solid target; Blanco slido; Monte Carlo simulation; Simulacin Monte Carlo; Cyclotron; Ciclotrn] |
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| Materias: | Fsica > Fsica mdica |
| Divisiones: | FUESMEN |
| Cdigo ID: | 1232 |
| Depositado Por: | Marisa G. Velazco Aldao |
| Depositado En: | 11 Abr 2024 12:27 |
| ltima Modificacin: | 11 Abr 2024 14:56 |
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