Castrillón Fernández, Manuel J. (2010) Medición no invasiva de la concentración de hierro en hígado mediante resonancia magnética nuclear de 1.5T / Non invasive measurement of liver iron concentration with 1.5T nuclear magnetic resonance. Maestría en Física Médica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
Esta tesis describe la implementación de un método para la medición no invasiva de la concentración de hierro en el hígado (CHH) usando imágenes de resonancia magnética (IRM) nuclear de 1.5T. La biopsia punzante es la técnica gold standard que permite una medición directa de la CHH por espectroscopia de absorción atómica y una evaluación histológica de la patología hepática. Sin embargo, la biopsia hepática no es utilizada como un método rutinario debido a que es invasivo, incómodo y de alto riesgo para el paciente. Además, el tamaño de la muestra es inadecuado y la no uniformidad de la distribución de hierro en el hígado puede dar resultados erróneos. Otro método ampliamente utilizado para evaluar la cantidad total de sobrecarga de hierro corporal es medir la concentración de ferritina en el suero sanguíneo, cuyo análisis representa una baja correlación para usarse como un valor de diagnóstico y pronóstico de enfermedades relacionadas con la sobrecarga de hierro. La medición de la CHH usando IRM, reduce el tiempo de análisis del valor de concentración de hierro, debido a que la biopsia debe ser realizada por un médico especialista y su estudio tarda en ser evaluado. Igualmente, esta técnica permite un apoyo visual a los especialistas y fortalece las pruebas realizadas con las otras técnicas utilizadas, para darle al paciente un diagnóstico rápido, económico y no invasivo. Además de ser apropiada para monitorear los tratamientos quelantes, evaluando la respuesta al tratamiento a lo largo del tiempo, para evitar riesgos y dar pronósticos acertados durante su uso. Este trabajo presenta los resultados de un estudio en el campo de las imágenes médicas, que se basó en la elaboración de una rutina software que permite cuantificar la concentración de hierro en el hígado, mediante la técnica de relaxometría R2 o medición de la tasa de relajación de la magnetización transversal, obtenida a partir de IRM.
Resumen en inglés
This thesis describes the implementation of a method for noninvasive measurement of the liver iron concentration (LIC) using magnetic resonance imaging (MRI) of 1.5T. Puncture biopsy is the gold standard technique that allows direct measurement of LIC by atomic absorption spectroscopy and histological assessment of liver pathology. However, liver biopsy is not used as a routine method because it is invasive, uncomfortable and risky for the patient. In addition, the sample size is inadequate and the non-uniformity of the distribution of iron in the liver may give erroneous results. One widely used to assess total body iron overload is to measure the concentration of ferritin in blood serum, which represents a low correlation analysis for use as a diagnostic and prognostic value of disease related to iron overload. Measurement of LIC using MRI scanning, reduces the analysis time of iron concentration value, because the biopsy should be performed by a medical specialist and the study delay to be evaluated. Also, this technique provides a visual support to specialists and strengthens the tests carried out on other techniques, to give the patient a rapid, inexpensive and not invasive diagnosis. In addition, to being appropriate to monitor chelation therapy, evaluating treatment response over time, to avoid risks and provide accurate prognosis during use. This paper presents the results of a study in the field of medical imaging, which was based on the development of a software routine to quantify the concentration of iron in the liver using R2 relaxometry technique or measurement of transverse magnetization relaxation rate, obtained from MRI.
| Tipo de objeto: | Tesis (Maestría en Física Médica) |
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| Palabras Clave: | Nuclear magnetic resonance; Resonancia magnética nuclear; Liver; Hígado; Ferritin; Ferritina; Magnetic resonance imaging; Imágenes de resonancia magnética; Relaxometry; Relaxometría |
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| Materias: | Medicina > Diagnóstico por imagen y medicina nuclear |
| Divisiones: | FUESMEN |
| Código ID: | 244 |
| Depositado Por: | Marisa G. Velazco Aldao |
| Depositado En: | 17 Feb 2011 09:49 |
| Última Modificación: | 17 Feb 2011 09:49 |
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