Cárdenas Szigety, Rodrigo (2013) Evaluación del desplazamiento de las fuentes y los cambios de dosis-volumen después del implante permanente de braquiterapia de baja tasa de dosis para tumores de próstata. / Seeds displacement and dose-volume changes assessment after permanent LDR prostate brachytherapy. Maestría en Física Médica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
Waterman et al. han observado la existencia de edema prostático luego de la realización de implantes permanentes de braquiterapia de próstata como tratamiento terapéutico y/o paliativo de adenocarcinoma de próstata. Este edema provoca el cambio de volumen prostático y el movimiento de las fuentes implantadas. Los cambios afectan la dosimetría planificada para el tratamiento. El comportamiento del edema es decreciente en forma exponencial con el tiempo y puede ser descripto mediante dos parámetros que son su magnitud y su tiempo de resolución. En este trabjo se analizan los datos de pacientes tratados con braquiterapia permanente de próstata con semillas de 125 Ι en el Instituto Oncológico Ángel H. Roffo para determinar la correlación de la magnitud del edema con parámtros quirúrgicos, del paciente y de la dosis administrada. También se realizaron simulaciones numéricas mediante un código desarrollado en MATLAB que incorpora a la dosimetría de braquiterapia el efecto del edema. De esta forma, se realizaron simulaciones variando los parámetros del edema y evaluando cómo impacta el edema en la dosimetría general y en los valores de los índices de calidad del tratamiento CI, DHI, DNR y ODI. Con esta herramienta se simularon los índices de calidad para los pacientes estudiados considerando el edema y se compararon estos resultados con las dosimetrías intraoperatoria y de post-implante. Por último se realizó una evaluación del tiempo de post-implante para el cual se obtendrán los mismos valores de índices dosimétricos calculados considerando el edema.
Resumen en inglés
Waterman et al. have observed existence of prostatic edema after perform of therapeutic or palliative permanent prostate brachytherapy for prostate adenocarcinoma. The edema produces changes on prostate volume and movement of implanted radioactive sources. These changes affect the calculated dosimetry of the treatment. The edema decreases exponentially and it can be characterized by two parameters: magnitude of edema and the time in which edema resolves. In this thesis, data of patients treated with permanent prostate brachytherapy with 125 I seeds in Instituto Oncológico Ángel H. Roffo were analyzed in order to determinate the correlation between edema magnitude with surgical and patient-dependent parameters and with intensity of radiation implanted. Also, numerical simulations performed by a developed MATLAB code were done. The code incorporates to the brachytherapy dosimetry a prostate edema model. On this way, simulations were performed varying the edema parameters and studies of their impact on dosimetry and the quality indices CI, DHI, DNR and ODI were done. With this tool, quality indices were simulated for studied patients and these results were compared with their intraoperative and post-implant dosimetry. Finally, were calculated the optimum screening time in which post-implant quality indices are equal to those calculated taking edema into account.
| Tipo de objeto: | Tesis (Maestría en Física Médica) |
|---|---|
| Palabras Clave: | Prostate, Prostata, Brachytherapy, Braquiterapia, Edema, Neoplasms, Neoplasmas, [Quality indices, Índices de calidad] |
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| Materias: | Medicina > Oncología |
| Divisiones: | ROFFO |
| Código ID: | 434 |
| Depositado Por: | Marisa G. Velazco Aldao |
| Depositado En: | 04 Abr 2014 13:12 |
| Última Modificación: | 04 Abr 2014 13:12 |
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