Brezán, Rocío (2017) Puesta en servicio de las modalidades terapéuticas de IMRT y VMAT en acelerador lineal con colimador multiláminas. / IMRT and VMAT commissioning for an Elekta LINAC with multileaf collimator. Maestría en Física Médica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
En este trabajo se realizó la puesta en servicio de la técnica de Radioterapia de Intensidad Modulada (IMRT, del inglés Intensity Modulated Radiation Therapy), en el acelerador lineal Elekta Synergy del Centro Integral de Medicina Nuclear y Radioterapia de Bariloche, cuya gestión es llevada a cabo por la Fundación INTECNUS. Para esto, se realizaron pruebas end to end en la modalidad Step and Shoot y Terapia en Arco Modulada Volumetricamente (VMAT, del ingles Volumetric Modulated Arc Therapy) sobre un fantoma sólido, y en Step and Shoot, Sliding Window y VMAT sobre un fantoma antropomórfico de tórax. Se efectuaron mediciones durante tales pruebas con una cámara de ionización, películas radiocrómicas y un arreglo de detectores 2D que fueron comparadas con datos calculados en el Sistema de Plani- cación de Tratamiento (TPS, del ingles Treatment Planning System) mediante el ndice gamma con criterio de aceptación 3 %/3mm. Por otro lado, se analizaron las funciones de costo que el TPS utiliza para representar las dosis deseadas en el blanco tumoral y las dosis toleradas en los órganos de riesgo, mediante un análisis cualitativo de histogramas dosis-volumen entre dos planes de un mismo tratamiento, uno realizado a partir de modelos biológicos y otro a partir de parámetros físicos. Ademas, se llevo a cabo la caracterización del escáner para lectura de películas radiocrómicas. Se encontraron resultados satisfactorios en los análisis realizados, principalmente en aquellos implementados en Step and Shoot, y se estableció que el arreglo de detectores 2D es apto para realizar controles de calidad paciente-específico en tratamientos de IMRT. Se plantearon las variables que deben continuar investigandose en trabajos futuros para complementar este estudio.
Resumen en inglés
The aim of this work was to perform the commissioning of the Intensity Modulated Radiation Therapy (IMRT) technique, on an Elekta Synergy linear accelerator, available in the radiotherapy service of the \Centro Integral de Medicina Nuclear y Radioterapia de Bariloche", managed by \Fundacion INTECNUS". In order to achieve this goal, end-to-end tests were conducted in both Stepand- Shoot and Volumetric Modulated Arc Therapy (VMAT) techniques on a solid phantom, as well as tests in Step-and-Shoot, Sliding Window and VMAT techniques for an anthropomorphic thoracic phantom. During the course of such tests, measurements using an ionization chamber, radiochromic lms and a 2D detector array were obtained and compared against Treatment Planning System (TPS) calculations, by means of the gamma index with acceptance criteria of 3 %/3mm. On the other hand, the cost functions used by the TPS to represent the desired doses on the target, as well as the tolerated doses on risk organs, were analyzed using dose-volume histograms to compare two plans for the same treatment, one of them using biological models and the other based on physical parameters. In addition to this, the characterization of the scanner used to read the radiochromic lms was performed. Results obtained from these analyses were deemed satisfactory, specially those using a Step-and-Shoot technique. We concluded that the 2D detector array was suitable for performing patient-specic quality controls on IMRT. Finally, other variables that would require further investigation in order to complement this work were identified.
| Tipo de objeto: | Tesis (Maestría en Física Médica) |
|---|---|
| Palabras Clave: | Linear accelerators; Aceleradores lineales; Thorax; Pecho; Collimators; Colimadores; [INTECNUS; Intensity modulated radiation therapy; Radioterapia de intensidad modulada; Solid phantom; Fantoma sólido; Anthropomorphic thoracic phantom; Fantoma antropomórfico] |
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| Materias: | Medicina > Radioterapia |
| Divisiones: | Gerencia Centro Integral de Medicina Nuclear y Radioterapia de Bariloche |
| Código ID: | 688 |
| Depositado Por: | Tamara Cárcamo |
| Depositado En: | 23 Aug 2018 13:27 |
| Última Modificación: | 23 Aug 2018 13:27 |
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