Valdés, Daniela Paola (2018) Modelando el efecto de las interacciones dipolares en cadenas de nanopartículas para hipertermia magnética. / Modeling the effect of dipolar interactions in chains of nanoparticles. Maestría en Ciencias Físicas, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
La hipertermia magnética, que está siendo estudiada como un tratamiento para el cáncer, consiste en la incorporación de nanopartículas magnéticas en un tumor y su subsecuente calentamiento mediante un campo magnético alterno. El aumento de temperatura de la zona tumoral por encima de los 42 C puede causar la muerte de las células cancerégenas. El punto clave del tratamiento es la capacidad de las nanopartículas de absorber energía del campo magnético y de posteriormente convertirlo en calor, lo que depende de características morfológicas, magnéticas y reológicas. Este trabajo tiene como objetivo estudiar el efecto de las interacciones dipolares entre nanopartículas sobre el área de los ciclos de histéresis de la magnetización cuando éstas se ordenan en un arreglo de cadenas con anisotropía uniaxial. Un aumento en el área de los ciclos significa una mayor capacidad de absorber potencia del campo alterno por unidad de masa de las partículas. Para abordar este estudio, se tomó un modelo de relajación magnética no lineal y se lo modicó con el fin de agregar interacciones dipolares. Mediante su implementación, se estudiaron cadenas de diferente longitud, orientadas en diferentes direcciones respecto al campo externo y con partículas con diferentes anisotropías, además de analizar el efecto de la frecuencia dentro en la región de interés experimental (100-1000 kHz). Se distinguieron 4 regiones de interés, definidas por la relación del campo coercitivo efectivo y la amplitud del campo externo. Estas regiones fueron caracterizadas exhaustivamente. Se tomaron en cuenta las componentes del campo dipolar paralela y perpendicular al campo magnético externo en el análisis. Los estudios mostraron que en las regiones de menor anisotropía, las interacciones en cadenas ayudan a aumentar el área del ciclo de histéresis y en el caso de alta anisotropía, perjudican. Se pudo estudiar el caso de cadenas orientadas en diferentes direcciones respecto al campo así como el de cadenas distribuidas al azar. Se observó que las componentes del campo dipolar también presentan histéresis y que los cambios en sus ciclos tienen efectos que se reflejan en el ciclo de la magnetización.
Resumen en inglés
Magnetic hyperthermia is being studied as a cancer treatment and consists in the incorporation of magnetic nanoparticles in a tumor with their subsequent heating through the application of an alternating magnetic field. The increase of temperature of the tumoral zone above 42 C may cause the death of cancerigen cells. The key point of the treatment is the ability of the nanoparticles to absorb energy from the magnetic eld and then convert it into heat, which depends on morphological, magnetic and rheological characteristics. This work aims to study the effect of the dipolar interactions between nanoparticles on the area of the magnetization hysteresis loops when they are arranged in chains with uniaxial anisotropy. An increment in the area of the loops means a greater capacity to absorb power from the alternate eld per unit mass of the particles. To address this study, a non-linear magnetic relaxation model was modied to add dipolar interactions. Through its implementation, chains of different lengths, oriented in dierent directions regarding the external eld and with particles with different anisotropy values were studied. The effect of frequency was analyzed for the range of interest for the experiments (100-1000 kHz). Four regions of interest were distinguished, dened by the relation between the effective coercive eld and the amplitude of the external field. These regions were characterized extensively. The components of the parallel and perpendicular dipolar field were taken into account for this analysis. Our study showed that for regions of low anisotropy, the interactions in chains help to increase the area of the hysteresis loops and, for those of high anisotropy, they are detrimental. It was possible to study the case of chains oriented in different directions regarding the eld as well as that of chains distributed randomly. It was observed that the components of the dipolar eld also present hysteresis and that the changes in their cycles have effects that are reflected in the magnetization loops.
| Tipo de objeto: | Tesis (Maestría en Ciencias Físicas) |
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| Palabras Clave: | Hyperthermia; Hipertermia; Hysteresis; Histeresis; [Magnetic nanoparticles; Nanopartículas magnéticas; Dipolar interactions; Interacciones dipolares; dipolar fields; Campos dipolares; Nanomedicine; Nanomedicina ] |
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| Materias: | Física > Nanotecnología Física > Física del estado sólido Medicina |
| Divisiones: | Gcia. de área de Investigación y aplicaciones no nucleares > Gcia. de Física > Ciencias de materiales > Resonancias magnéticas |
| Código ID: | 748 |
| Depositado Por: | Tamara Cárcamo |
| Depositado En: | 08 Oct 2019 13:52 |
| Última Modificación: | 08 Oct 2019 13:52 |
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