Gordillo Olivera, Carlos N. (2018) Desarrollo de técnicas cuantitativas de mapping y feature tracking en resonancia magnética para diagnóstico clínico de patologías cardíacas. / Development of quantitative mapping and feature tracking techniques in magnetic resonance for clinical diagnosis of cardiac pathologies. Maestría en Física Médica, Universidad Nacional de Cuyo, Instituto Balseiro.
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Resumen en español
En la práctica clínica de rutina la caracterización tisular del miocardio de forma cuantitativa ha adquirido importancia diagnóstica en la determinación de patologías como brosis. La creciente demostración de capacidad diagnostica de la técnica T_1 mapping ha llevado a implementarla en forma rutinaria en los estudios cardíacos. La Fundacion Escuela de Medicina Nuclear (FUESMEN) dispone de un resonador Signa PET-MR 3T y un Optima MR450wGEM (General Electric Healthcare) donde se atienden mensualmente aproximadamente 20 pacientes por estudios cardíacos. En forma rutinaria se utiliza la secuencia CineIR 2RR (GE) en principio para la búsqueda de un valor T_I_null que optimice la evaluación de viabilidad miocárdica. Sin embargo, se planteo la hipótesis de que esta secuencia tenía un gran potencial para poder realizar T_1 mapping. Para poder validar esta hipótesis se realizaron en primer lugar mediciones en fantomas cilíndricos con solución fisiológica y cantidades crecientes de material de contraste (Gd). Estas mediciones consistieron en aplicar la secuencia IR modicando el valor de T_I , reconocida como aquella capaz de determinar el T_1 "real", y luego se ejecuto la secuencia CineIR 2RR para comparar los valores de determinados cada una. De esta forma se logra validar la potencialidad de la secuencia CineIR 2RR para T_1 mapping. Se diseño un software en Matlab para poder analizar las imágenes obtenidas. Se lo utilizo con los fantomas y posteriormente en imágenes obtenidas de las secuencias de rutina de pacientes con la incorporación de un CineIR 2RR pre-contraste. Se adopto un criterio de separación de pacientes en "normales" y "fibroticos" en base a informes médicos y se procedió a determinar valores normales de T_1 nativo, post-contraste y de ECV. Se estudiaron también pacientes con patologías específicas: brosis septal aguda, brosis difusa, aminoácidos, enfermedad de Fabry y miocardiopatía hipertroca para evaluar la sensibilidad del T_1 mapping ante ellas. Se estudiaron los métodos de flujo óptico de Horn y Schunk y Lucas y Kanade con el objetivo de evaluar su rendimiento en la aplicación de secuencias cine de mid-eje corto. Esto se tomo como una primera aproximación al desarrollo de un software de feature tracking con potencial utilización clínica.
Resumen en inglés
In routine clinical practice, the tissue characterization of the myocardium in a quantitative way has acquired diagnostic importance in the determination of pathologies such as brosis. The increasing demonstration of diagnostic capacity of the T_1 mapping technique has led to its routine implementation in cardiac studies. The Fundacion Escuela de Medicina Nuclear (FUESMEN) has a Signa PET-MR 3 T resonator and an Optima MR450wGEM (General Electric Healthcare) where approximately 20 patients are treated monthly for cardiac studies. The CineIR 2RR sequence (GE) is routinely used in principle to search for a value T_I_null that optimizes the evaluation of myocardial viability. However, it was hypothesized that this sequence had great potential to be able to make T_1 mapping. In order to validate this hypothesis, measurements were rst made on cylindrical phantoms with physiological solution and increasing amounts of contrast material (Gd). These measurements consisted in applying the IR sequence modifying the value of T_I , recognized as being able to determine the \real" T_1, and then executing the CineIR 2RR sequence to compare the values of each determined. In this way it is possible to validate the potential of the CineIR 2RR sequence for T_1 mapping. A software was designed in Matlab to analyze the images obtained. It was used with the phantoms and later on images obtained from the routine sequences of patients with the incorporation of a CineIR 2RR pre-contrast. A criterion for the separation of patients into " normal " and "fibrotic " was adopted based on medical reports and normal values of T_1 native, post-contrast and CVD were determined. Patients with specic pathologies were also studied: acute septal brosis, diffuse brosis, amyloidosis, Fabry disease and hypertrophic cardiomyopathy to evaluate the sensitivity of the mapping before them. The optical flow methods of Horn and Schunk and Lucas and Kanade were studied in order to evaluate their performance in the application of short mid-axis cine sequences. This was taken as a rst approach to the development of feature tracking software with potential clinical use.
| Tipo de objeto: | Tesis (Maestría en Física Médica) |
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| Palabras Clave: | Magnetic resonance; Resonancia magnética, Fibrosis; [Myocardiopathies; Miocardiopatías; Mapping; Feature tracking; Sofware ] |
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| Materias: | Medicina > Resonancia magnética |
| Divisiones: | FUESMEN |
| Código ID: | 774 |
| Depositado Por: | Tamara Cárcamo |
| Depositado En: | 05 Abr 2019 13:05 |
| Última Modificación: | 05 Abr 2019 13:08 |
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